Chloride channels are involved in sperm motility and are downregulated in spermatozoa from patients with asthenozoospermia

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Chloride channels are involved in sperm motility and are downregulated in spermatozoa from patients with asthenozoospermia

Human spermatozoa encounter an osmotic decrease from 330 to 290 mOsm l-1 when passing through the female reproductive tract. We aimed to evaluate the role of chloride channels in volume regulation and sperm motility from patients with asthenozoospermia. Spermatozoa were purified using Percoll density gradients. Sperm volume was measured as the forward scatter signal using flow cytometry. Sperm ...

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ATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice

Introduction: We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. Methods: We used a hotplate apparatus to assess pain behavior in male NMRI mice. Nociceptive sensitization was induced by three days injection of morphine and five days of drug free. On day 9 of the schedule, pain behavior te...

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atp-sensitive potassium channels and l-type calcium channels are involved in morphine-induced hyperalgesia after nociceptive sensitization in mice

introduction: we investigated the role of atp-sensitive potassium channels and l-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. methods: we used a hotplate apparatus to assess pain behavior in male nmri mice. nociceptive sensitization was induced by three days injection of morphine and five days of drug free. on day 9 of the schedule, pain behavior test ...

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Proteins Involved in Motility and Sperm-Egg Interaction Evolve More Rapidly in Mouse Spermatozoa

Proteomic studies of spermatozoa have identified a large catalog of integral sperm proteins. Rapid evolution of these proteins may underlie adaptive changes of sperm traits involved in different events leading to fertilization, although the selective forces underlying such rapid evolution are not well understood. A variety of selective forces may differentially affect several steps ending in fe...

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ژورنال

عنوان ژورنال: Asian Journal of Andrology

سال: 2017

ISSN: 1008-682X

DOI: 10.4103/1008-682x.181816